High Purity Pharmaceutical Raw Materials AMoxicillin And
Clavulanate Potassium CAS: 61177-45-5
Chinese name: Amoxicillin And Clavulanate Potassium Powder
CAS No.: 61177-45-5
Molecular Formula: C8H8KNO5
Molecular Weight: 237.2511
Grade Standard: Medicine Grade
Quality Standard: BP/EP/USP
Appearance: White or yellowish crystalline powder
Usage: Animal Pharmaceuticals.
Application: Pharmaceutical Raw Intermediates
It is white or yellowish crystalline powder; Slight odor. Very easy
to get wet. It is easily soluble in water, soluble in methanol,
slightly soluble in ethanol, insoluble in ether. Boiling point
545.8°C at 760 mmHg, Flash point 283.9°C, Vapour Pressur
3.45E-14mmHg at 25°C.
|Appearance||White or almost white crystalline powder hygroscopic||White powder, hygroscopic|
|Identification Tests||HPLC: The principal peaks in the chromatogram obtained with the
test solution is similar in retention time to that obtained with
|Ratio of compound||Amoxicillin:clavulanic acid(1.9~2.1):1||2.0:1|
|Related substances||Any individual impurity(largest), NMT 2.0%||0.12%|
|Total impurities, NMT 5.0%||0.52%|
|Assay on the anhydrous basis||Clavulanic acid, NMT25.8%||30.9%|
|Conclusion||The results conforms with enterprise standards|
1. Clavulanic Acid is a β-lactamase inhibitor, typically added to
amoxicillin to increase its effectiveness.
2. Clavulanic acid is a β-lactam antibiotic produced by several
species of Streptomyces. The free acid degrades and is isolated and
maintained as either the sodium or potassium salt. Clavulanate is a
weak antibiotic, but is a potent inhibitor of β-lactamases. In
combination with penicillin and cephalosporins, it shows potent
synergistic activity. Clavulanic acid is a suicide inhibitor,
covalently binding to a serine residue in the active site of the
3. A -Lactamase inhibitor, typically added to amoxicillin to
increase its effectiveness.
25kg/drum, 1kg/ aluminium foil bag, Or according to your
Store in a shady place, keep sealed. Storage Condition 2-8ºC.
AMoxicillin and Clavulanate Potassium is not reversible competitive inhibitors of beta-lactamase, firmly
binding enzyme inactivation of the enzyme, so powerful, not only
gold aureus of beta-lactamase, and Gram-negative bacilli of
beta-lactamase. Penicillins, cephalosporin class combined with
greatly increased antimicrobial activity, can make the minimum
inhibitory concentration (MIC) decreased drug effect several times
to more than 10 times, drug-resistant strains to recover its
sensitivity. This product is also known as clavulanic acid, new
oxygen nucleus produced by Streptomyces β-lactam antibiotics.
Potassium clavulanate for the needle-like crystals, soluble in
[Certification Of Analysis]: